folE [2019-08-07 08:15:19]

GTP cyclohydrolase I

Locus: BSU_22780

Isoelectric point: 6.34

Molecular weight: 21.07 kDa

Protein length: 190 aa

Gene length: 573 bp

Function: biosynthesis of folate

Product: GTP cyclohydrolase IA

Essential: yes

E.C.: 3.5.4.16

Synonyms

Genomic Context

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Categories containing this gene/protein

• Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis of folate
• Information processing → Protein synthesis, modification and degradation → Translation → tRNA modification and maturation
• Groups of genes → Essential genes

Gene

Coordinates: 2,384,783 2,385,355

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• GTP + H₂O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate (according to Swiss-Prot)

Protein family

• GTP cyclohydrolase I family (with QueF, according to UniProt)

Cofactors

• zinc-dependent enzyme PubMed

Effectors of protein activity

• the interaction with ZagA/ZTP facilitates the supply of zinc to FolE under conditions of zinc limitation, and thus enzymatic activity PubMed

Structure

• 3D2O (enzyme from Neisseria gonorrhoeae) PubMed

Expression and Regulation

Operons

• Genes: folE-mtrB
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulation

  • constitutive PubMed

References

Reviews

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Original publications

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